The FDA has approved three prescription medications to help treat fibromyalgia pain:
- Pregabalin (Lyrica) was first used to treat seizures and nerve pain linked to diabetes. It affects nerve cells that help send pain signals. But it can cause side effects like sleepiness, dizziness, blurred vision, and trouble concentrating. It also may lead to weight gain, swelling in your hands and feet, and dry mouth. A small number of people have an allergic reaction to it.
- Duloxetine hydrochloride (Cymbalta) is an antidepressant that’s also been used to treat diabetic nerve pain. Its side effects include sleepiness, dry mouth, and sweating, as well as nausea, constipation, and a lack of appetite. In some people, it also can lead to suicidal thoughts and actions.
- Milnacipran (Savella) is the first drug designed specifically for fibromyalgia treatment. It affects brain chemicals linked to pain. It can cause things like nausea, constipation, dry mouth, dizziness, and sleep trouble for some people. It also may raise your heart rate or blood pressure.
Over-the-counter painkillers like ibuprofen, naproxen, or acetaminophenmay help ease some of the pain. But doctors don’t recommend opioidpainkillers, like oxycodone or hydrocodone, for fibromyalgia. These powerful medications don’t work as well for that condition as they do for other problems, and there’s a chance you might start to depend on them.